Porcn Inhibitor III

Name	2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)aceta
Synonyms	IWP L6 IWP-L6 CS-1445 Porcn Inhibitor III IWP L6 (Porcn Inhibitor III) 2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)aceta 2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide 2-[(4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyriMidin-2-yl) sulfanyl]-N-(5-phenyl-2-pyridinyl)acetaMide N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide IWP-L6
CAS	1427782-89-5

Molecular Formula	C25H20N4O2S2
Molar Mass	472.58
Storage Condition	2-8℃
In vitro study	IWP-L6 blocks the phosphorylation of cytoplasmic Wnt pathway effector Dvl2 in HEK293 cells. In cultured embryonic kidney, IWP-L6 also inhibited Wnt-mediated branching morphogenesis by reversibly blocking Wnt signaling. IWP-L6 blocked the phosphorylation of cytoplasmic Wnt pathway effector Dvl2 in HEK293 cells. In cultured embryonic kidney, IWP-L6 also inhibited Wnt-mediated branching morphogenesis by reversibly blocking Wnt signaling.
In vivo study	IWP-L6 in human plasma can be stable for more than 24 hours, while in rat plasma (t1/2=190 minutes), mouse plasma (t1/2=2 minutes), and rapid metabolism in the S9 fraction of the mouse liver. In zebrafish embryos, IWP-L6 effectively inhibited posterior axis formation, a Wnt/β catenin-dependent development process. IWP-L6 was stable for more than 24 hours in human plasma, while in rat plasma (t1/2=190 min), mouse plasma (t1/2=2 min), and rapid metabolism in the S9 fraction of the mouse liver. In zebrafish embryos, IWP-L6 effectively inhibited posterior axis formation, a Wnt/β catenin-dependent development process.

Last Update：2024-01-02 23:10:35

biological activity	IWP-L6 is a potent Porcn inhibitor with EC50 of 0.5 nM. IWP-L6 (Porcn Inhibitor III) is a highly effective and potent Porcn inhibitor with EC50 of 0.5 nM.
In vitro study	IWP-L6 block the phosphorylation of the cytoplasmic Wnt pathway effector Dvl2 in HEK293 cells. In cultured embryonic kidneys, IWP-L6 also inhibited Wnt-mediated branching morphogenesis by reversibly blocking Wnt signaling. IWP-L6 blocks phosphorylation of cytoplasmic Wnt pathway effector Dvl2 in HEK293 cells. In cultured embryonic kidneys, IWP-L6 also inhibited Wnt-mediated branching morphogenesis by reversibly blocking Wnt signaling.
in vivo studies	IWP-L6 can be stabilized for more than 24 hours in human plasma, while it is rapidly metabolized in rat plasma (t1/2=190 minutes), mouse plasma (t1/2=2 minutes), and mouse liver S9 components. In zebrafish embryos, IWP-L6 effectively inhibit the formation of posterior axis, a Wnt/β catenin-dependent development process. IWP-L6 can be stable in human plasma for more than 24 hours, while it is rapidly metabolized in rat plasma (t1/2=190 minutes), mouse plasma (t1/2=2 minutes), and mouse liver S9 components. In zebrafish embryos, IWP-L6 effectively inhibit the formation of posterior axis, a Wnt/β catenin-dependent development process.
target	TargetValue Porcn 0.5 nM(EC50)
Target	Value
Porcn	0.5 nM(EC50)